Cherish every minute of this moving, intimate and sometimes humorous slice of life in poverty-ridden East London in the 1950s, as seen through the eyes of young, innocent midwife Jenny Lee. Fresh from nursing school, Jenny joins a team of midwives at Nonnatus House, a nursing convent, and makes friends with good-time Trixie, sensible Cynthia and fish-out-of-water Chummy. Join these caring women as they make their rounds on bikes, serving the needy. Based on the best-selling memoirs of Jennifer Worth.

— Episode 1 In the spring of 1957, newly minted midwife Jenny Lee arrives in the East End of London to begin her career. After overcoming the initial shock that her new home, Nonnatus House, is a convent and not a private hospital, she quickly becomes immersed in her new life. Living with nuns and working in a community of colorful characters are different from anything Jenny has previously encountered. Through her, experience the sorrows and joys that come with being a midwife. Episode 2 As Jenny Lee settles into her role, there is a new arrival at Nonnatus House — Chummy. A welcome pair of extra hands, Chummy sets about showing her worth, but her overwhelming desire to please and her inability to ride a bike prove obstacles in gaining the respect of Sister Evangelina. Meanwhile, a chance encounter with Mary, a pregnant young runaway, forces Jenny to see an unfamiliar, darker side of life. Episode 3 Jenny is placed on the district nursing roster for a few weeks, to extend her experience of community practice. During her rounds, she attends to Joe, a gentle old soldier, and a friendship forms. At the antenatal clinic, Trixie and Cynthia enroll Winnie as a new patient. In her 40s, Winnie, who thought her days of diapers and babies were long gone, seems upset by her pregnancy. By contrast, her husband, Ted, is overjoyed. However, at the baby’s birth, everyone gets a little surprise. Episode 4 A baby girl, recently delivered by Jenny, is snatched from her baby carriage, causing great anguish to her family and uniting the local community as they search for the missing child. Meanwhile, Cynthia witnesses another type of loss as she assists in the case of soon-to-be parents David and Margaret. Newly married and excited about their future, everything is put in jeopardy when Margaret develops eclampsia. Episode 5 Jenny finds herself for once not involved in the beginning of life, but at its end. When Nonnatus House cleaner Peggy’s brother Frank is diagnosed with cancer, Jenny and the nuns are called upon to care for him. In doing so, Jenny comes to know the siblings better, learning of their upbringing in a workhouse and the profound effect it had on their relationship. Episode 6 Sister Monica Joan is found wandering near the docks and returned to Nonnatus House by the police. Her adventure takes its toll on her health and she develops pneumonia. When she eventually recovers she returns to the community, only to find herself in trouble with the law when she is accused of theft. As Sister Monica Joan’s case progresses to trial, the Nonnatus House community fears that the elderly nun could go to jail. Chummy is worried when her mother decides to make a trip to “inspect” her new beau..